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, Yu-Ming Chen 1Department of Community and Family Medicine (Y.-M.C., S.C.H., S.S.H.L.), Hong Kong; 4School of Public Health, Sun Yat-sen University (Y.-M.C.), Guangzhou, Peoples Republic of China 510275 Search for other works by this author on: Oxford Academic Suzanne C. Ho 1Department of Community and Family Medicine (Y.-M.C., S.C.H., S.S.H.L.), Hong Kong; *Address all correspondence and requests for reprints to: Dr. Suzanne C. Ho, Department of Community and Family Medicine, Chinese University of Hong Kong, 4th Floor, School of Public Health, Prince of Wales Hospital, Shatin, N.T., Hong Kong SAR. Search for other works by this author on: Oxford Academic Silvia S. H. Lam 1Department of Community and Family Medicine (Y.-M.C., S.C.H., S.S.H.L.), Hong Kong; Search for other works by this author on: Oxford Academic Susan S. S. Ho 2School of Pharmacy (S.S.S.H.),, Hong Kong; Search for other works by this author on: Oxford Academic Jean L. F. Woo 3Department of Medicine and Therapeutics (J.L.F.W.), Chinese University of Hong Kong, Hong Kong; Search for other works by this author on: Oxford Academic
The Journal of Clinical Endocrinology & Metabolism, Volume 88, Issue 10, 1 October 2003, Pages 4740–4747, https://doi.org/10.1210/jc.2003-030290
Published:
01 October 2003
Article history
Received:
20 February 2003
Accepted:
11 July 2003
Published:
01 October 2003
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Yu-Ming Chen, Suzanne C. Ho, Silvia S. H. Lam, Susan S. S. Ho, Jean L. F. Woo, Soy Isoflavones Have a Favorable Effect on Bone Loss in Chinese Postmenopausal Women with Lower Bone Mass: A Double-Blind, Randomized, Controlled Trial, The Journal of Clinical Endocrinology & Metabolism, Volume 88, Issue 10, 1 October 2003, Pages 4740–4747, https://doi.org/10.1210/jc.2003-030290
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Abstract
Animal studies have shown that soy isoflavones have an effect in preventing estrogen-related bone loss, but few data are available in humans, especially in the Asian populations. This double-blind, placebo-controlled, randomized trial examines the effects of soy isoflavones on bone loss in postmenopausal Chinese women, aged 48–62 yr. Two hundred and three eligible subjects were randomly assigned to three treatment groups with daily doses of placebo (1 g starch; n = 67), mid-dose (0.5 g starch, 0.5 g soy extracts, and ∼40 mg isoflavones; n = 68), and high dose (1.0 g soy extracts and ∼80 mg isoflavones; n = 68). All were given 12.5 mmol (500 mg) calcium and 125 IU vitamin D3. Bone mineral density (BMD) and bone mineral content (BMC) of the whole body, spine, and hip were measured using dual energy x-ray absorptiometry at baseline and 1 yr post treatment. Both univariate and multivariate analyses showed that women in the high dose group had mild, but statistically significantly, higher favorable change rate in BMC at the total hip and trochanter (P < 0.05) compared with the placebo and mid-dose groups, even after further adjustments for the potential confounding factors. Further stratified analyses revealed that the positive effects of soy isoflavone supplementation were observed only among women with lower initial baseline BMC (median or less). In conclusion, soy isoflavones have a mild, but significant, independent effect on the maintenance of hip BMC in postmenopausal women with low initial bone mass.
Copyright © 2003 by The Endocrine Society
Issue Section:
Endocrine Care
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